Colletotrichine A, a new sesquiterpenoid from Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla

Xiao-Wei Chen; Zhong-Duo Yang; Jian-Hui Sun; Tong-Tong Song; Bao-Ying Zhu; Jun-Wen Zhao

doi:10.1080/14786419.2017.1365071

Colletotrichine A, a new sesquiterpenoid from Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla

Nat Prod Res. 2018 Apr;32(8):880-884. doi: 10.1080/14786419.2017.1365071. Epub 2017 Aug 14.

Authors

Xiao-Wei Chen¹, Zhong-Duo Yang^{1

2}, Jian-Hui Sun¹, Tong-Tong Song¹, Bao-Ying Zhu¹, Jun-Wen Zhao¹

Affiliations

¹ a School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , P.R. China.
² b The Provincial Education Key Laboratory of Screening, Evaluation and Advanced Processing of Traditional Chinese Medicine and Tibetan Medicine, School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , P.R. China.

PMID: 28805453
DOI: 10.1080/14786419.2017.1365071

Abstract

One new compound, Colletotrichine A (1), was produced by the fungal Colletotrichum gloeosporioides GT-7. The structure was established by 1D and 2D NMR spectra. Monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibitory activity of 1 was also evaluated. Compound 1 showed AChE-inhibiting activity with IC₅₀ value of 28 μg/mL.

Keywords: Acetylcholinesterase inhibitor; Colletotrichum gloeosporioides; Uncaria rhynchophylla; sesquiterpenoid.

MeSH terms

Cholinesterase Inhibitors / chemistry*
Cholinesterase Inhibitors / pharmacology
Colletotrichum / chemistry*
Endophytes / chemistry
Inhibitory Concentration 50
Monoamine Oxidase Inhibitors / chemistry*
Monoamine Oxidase Inhibitors / pharmacology
Sesquiterpenes / chemistry*
Sesquiterpenes / pharmacology
Uncaria / microbiology*

Substances

Cholinesterase Inhibitors
Monoamine Oxidase Inhibitors
Sesquiterpenes