Palladium nanoparticles entrapped in a self-supporting nanoporous gold wire as sensitive dopamine biosensor

Xin Yi; Yuxuan Wu; Guoxin Tan; Peng Yu; Lei Zhou; Zhengnan Zhou; Junqi Chen; Zhengao Wang; Jinshan Pang; Chengyun Ning

doi:10.1038/s41598-017-07909-y

Palladium nanoparticles entrapped in a self-supporting nanoporous gold wire as sensitive dopamine biosensor

Sci Rep. 2017 Aug 11;7(1):7941. doi: 10.1038/s41598-017-07909-y.

Authors

Xin Yi^{1

2}, Yuxuan Wu³, Guoxin Tan⁴, Peng Yu^{5

6}, Lei Zhou^{7

2}, Zhengnan Zhou^{7

2}, Junqi Chen^{7

2}, Zhengao Wang^{7

2}, Jinshan Pang^{7

2}, Chengyun Ning^{8

9}

Affiliations

¹ School of Medicine, South China University of Technology, Guangzhou, China.
² Guangdong Key Laboratory of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou, 510006, China.
³ Department of Electronic Communication & Software Engineering, Nanfang College of Sun Yat-sen University, Guangzhou, China.
⁴ Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
⁵ School of Materials Science and Engineering, South China University of Technology, Guangzhou, China. conan424683@live.com.
⁶ Guangdong Key Laboratory of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou, 510006, China. conan424683@live.com.
⁷ School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
⁸ School of Materials Science and Engineering, South China University of Technology, Guangzhou, China. imcyning@scut.edu.cn.
⁹ Guangdong Key Laboratory of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou, 510006, China. imcyning@scut.edu.cn.

Abstract

Traced dopamine (DA) detection is critical for the early diagnosis and prevention of some diseases such as Parkinson's, Alzheimer and schizophrenia. In this research, a novel self-supporting three dimensional (3D) bicontinuous nanoporous electrochemical biosensor was developed for the detection of dopamine by Differential Pulse Voltammetry (DPV). This biosensor was fabricated by electrodepositing palladium nanoparticles (Pd) onto self-supporting nanoporous gold (NPG) wire. Because of the synergistic effects of the excellent catalytic activity of Pd and novel structure of NPG wire, the palladium nanoparticles decorated NPG (Pd/NPG) biosensor possess tremendous superiority in the detection of DA. The Pd/NPG wire biosensor exhibited high sensitivity of 1.19 μA μΜ^-1, broad detection range of 1-220 μM and low detection limit up to 1 μM. Besides, the proposed dopamine biosensor possessed good stability, reproducibility, reusability and selectivity. The response currents of detection in the fetal bovine serum were also close to the standard solutions. Therefore the Pd/NPG wire biosensor is promising to been used in clinic.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques / methods
Dopamine / analysis*
Gold / chemistry*
Limit of Detection
Metal Nanoparticles / chemistry*
Nanopores / ultrastructure
Nanowires / chemistry
Palladium / chemistry*

Substances

Palladium
Gold
Dopamine