Biphasic-to-monophasic successive Co-assembly approach to yolk-shell structured mesoporous organosilica nanoparticles

Meng Dang; Zhaogang Teng; Xiaodan Su; Jun Tao; Qing Hao; Xiaobo Ma; Yunlei Zhang; Yanjiao Li; Ying Tian; Junjie Zhang; Guangming Lu; Lianhui Wang

doi:10.1016/j.jcis.2017.08.008

Biphasic-to-monophasic successive Co-assembly approach to yolk-shell structured mesoporous organosilica nanoparticles

J Colloid Interface Sci. 2017 Dec 1:507:242-249. doi: 10.1016/j.jcis.2017.08.008. Epub 2017 Aug 3.

Authors

Meng Dang¹, Zhaogang Teng², Xiaodan Su¹, Jun Tao¹, Qing Hao¹, Xiaobo Ma¹, Yunlei Zhang³, Yanjiao Li⁴, Ying Tian³, Junjie Zhang¹, Guangming Lu⁵, Lianhui Wang¹

Affiliations

¹ Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, PR China.
² Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, PR China; Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, PR China; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China. Electronic address: zhaogangteng@163.com.
³ Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, PR China.
⁴ Department of Medical Imaging, Southeast Hospital of Xiamen University, Zhangzhou 363000, PR China.
⁵ Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, PR China; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.

PMID: 28800448
DOI: 10.1016/j.jcis.2017.08.008

Abstract

In this work, we report a facile biphasic-to-monophasic successive co-assembly approach to synthesize yolk-shell structured mesoporous organosilica nanoparticles (MONs). The yolk-shell structured MONs possess ethane-bridged frameworks, high surface area (1023m²g^-1), radially oriented mesochannels (3.8nm), large pore volume (0.99cm³g^-1), and tunable diameter (147-324nm) and shell thickness (23-53nm). The biphasic-to-monophasic successive co-assembly method is intrinsically simple and requires neither sacrificial templates nor multistep coating processes. The key of the method is that the interiors of the mesostructured organosilica nanospheres grown in the biphasic system have a lower condensation degree and Si-C-C-Si species content than the outer shells formed in the monophasic system. Thus, the interior layer is attracted by OH^-1 anions and dissolved in the monophasic system, forming the yolk-shell structures. In vitro cytotoxicity and haemolysis assays demonstrate that the ethane-bridged yolk-shell MONs possess excellent biocompatibility. Furthermore, the chemotherapy drug doxorubicin (DOX) is loaded into the yolk-shell MONs to kill drug-resistant MCF-7/ADR human breast cancer cells. Compared with free DOX and DOX-loaded typical MONs, the DOX-loaded yolk-shell MONs have higher chemotherapeutic efficacy against MCF-7/ADR cells, suggesting the great potential of yolk-shell MONs synthesized via the biphasic-to-monophasic successive co-assembly approach in the biomedical field.

Keywords: Biphasic-to-monophasic; Co-assembly; Mesoporous organosilica nanoparticles; Yolk–shell.