Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum

Abstract

To search for active anti-cancer constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four previously undescribed spiro-lactone lanostane triterpenoids (spiroganocalitones A-D), two previously undescribed lanostanoids (ganodecalones A and B) together with twenty-three known ones. The structures of the six previously undescribed compounds were elucidated based on 1D, 2D-NMR, and HRMS analyses. Ganoderone A showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC₅₀ values of 7.62, 6.28, and 3.55 μM, respectively.

Keywords: Cytotoxic activity; Ganoderma calidophilum; Ganodermataceae; Lanostane triterpenoid.