Chaetochromones A - C, Three New Polyketides from Mangrove Plant Derived Endophytic Fungus Phomopsis sp. SCSIO 41006

Chem Biodivers. 2017 Nov;14(11). doi: 10.1002/cbdv.201700266. Epub 2017 Oct 30.

Abstract

Three new polyketides, chaetochromones A - C (1 - 3), together with a chromone (4), were isolated from the ethyl acetate extract of mangrove-derived fungus Phomopsis sp. SCSIO 41006. Their structures were elucidated by means of spectroscopic techniques (UV, IR, MS, 1D- and 2D-NMR). The absolute configurations of the new compounds were established by CD data.

Keywords: Biological activities; Chaetochromones; Chromone; Phomopsis sp.; Polyketides.

MeSH terms

  • A549 Cells
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Chromones / chemistry
  • Chromones / isolation & purification
  • Chromones / pharmacology
  • Circular Dichroism
  • Fungi / classification
  • Fungi / isolation & purification
  • Fungi / metabolism*
  • Humans
  • K562 Cells
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Phylogeny
  • Polyketides / chemistry*
  • Polyketides / isolation & purification
  • Polyketides / pharmacology
  • Polyketides / toxicity
  • Rhizophoraceae / microbiology*
  • Salmonella typhi / drug effects
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Ultraviolet
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Infective Agents
  • Chromones
  • Polyketides

Associated data

  • GENBANK/KY661912
  • GENBANK/JF923840