Abstract
Three new polyketides, chaetochromones A - C (1 - 3), together with a chromone (4), were isolated from the ethyl acetate extract of mangrove-derived fungus Phomopsis sp. SCSIO 41006. Their structures were elucidated by means of spectroscopic techniques (UV, IR, MS, 1D- and 2D-NMR). The absolute configurations of the new compounds were established by CD data.
Keywords:
Biological activities; Chaetochromones; Chromone; Phomopsis sp.; Polyketides.
© 2017 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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A549 Cells
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Chromones / chemistry
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Chromones / isolation & purification
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Chromones / pharmacology
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Circular Dichroism
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Fungi / classification
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Fungi / isolation & purification
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Fungi / metabolism*
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Humans
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K562 Cells
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Phylogeny
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Polyketides / chemistry*
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Polyketides / isolation & purification
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Polyketides / pharmacology
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Polyketides / toxicity
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Rhizophoraceae / microbiology*
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Salmonella typhi / drug effects
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Ultraviolet
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Staphylococcus aureus / drug effects
Substances
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Anti-Infective Agents
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Chromones
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Polyketides
Associated data
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GENBANK/KY661912
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GENBANK/JF923840