Abstract
Rats subjected to a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion of the nigrostriatal dopamine pathway were given transplants of cultured fetal human sympathetic neurons. Amphetamine-induced turning behavior in these rats was reversed by the transplants after 1.5-4.5 months. The presence of transplanted neurons and their processes was demonstrated by immunohistochemistry for tyrosine hydroxylase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphetamine
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Animals
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Behavior, Animal / drug effects
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Catecholamines / metabolism
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Cells, Cultured
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Corpus Striatum / drug effects
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Corpus Striatum / metabolism
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Disease Models, Animal
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Fetus
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Ganglia, Sympathetic / cytology
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Ganglia, Sympathetic / physiology
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Ganglia, Sympathetic / transplantation*
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Humans
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Hydroxydopamines
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Oxidopamine
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Parkinson Disease, Secondary / chemically induced
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Parkinson Disease, Secondary / physiopathology*
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Substantia Nigra / drug effects
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Substantia Nigra / metabolism
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Tyrosine 3-Monooxygenase / metabolism
Substances
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Catecholamines
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Hydroxydopamines
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Oxidopamine
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Amphetamine
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Tyrosine 3-Monooxygenase