Functional recovery in a rat model of Parkinson's disease following transplantation of cultured human sympathetic neurons

Brain Res. 1986 Nov 12;397(2):372-6. doi: 10.1016/0006-8993(86)90641-4.

Abstract

Rats subjected to a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion of the nigrostriatal dopamine pathway were given transplants of cultured fetal human sympathetic neurons. Amphetamine-induced turning behavior in these rats was reversed by the transplants after 1.5-4.5 months. The presence of transplanted neurons and their processes was demonstrated by immunohistochemistry for tyrosine hydroxylase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamine
  • Animals
  • Behavior, Animal / drug effects
  • Catecholamines / metabolism
  • Cells, Cultured
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism
  • Disease Models, Animal
  • Fetus
  • Ganglia, Sympathetic / cytology
  • Ganglia, Sympathetic / physiology
  • Ganglia, Sympathetic / transplantation*
  • Humans
  • Hydroxydopamines
  • Oxidopamine
  • Parkinson Disease, Secondary / chemically induced
  • Parkinson Disease, Secondary / physiopathology*
  • Substantia Nigra / drug effects
  • Substantia Nigra / metabolism
  • Tyrosine 3-Monooxygenase / metabolism

Substances

  • Catecholamines
  • Hydroxydopamines
  • Oxidopamine
  • Amphetamine
  • Tyrosine 3-Monooxygenase