Clinical and Genetic Implications of DNA Mismatch Repair Deficiency in Patients With Pancreatic Ductal Adenocarcinoma

Jordan M Cloyd; Matthew H G Katz; Huamin Wang; Amanda Cuddy; Y Nancy You

doi:10.1001/jamasurg.2017.2631

Clinical and Genetic Implications of DNA Mismatch Repair Deficiency in Patients With Pancreatic Ductal Adenocarcinoma

JAMA Surg. 2017 Nov 1;152(11):1086-1088. doi: 10.1001/jamasurg.2017.2631.

Authors

Jordan M Cloyd¹, Matthew H G Katz¹, Huamin Wang², Amanda Cuddy¹, Y Nancy You¹

Affiliations

¹ Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston.
² Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston.

Abstract

This cohort study examines the behavior and outcomes of deficient DNA mismatch repair in patients at elevated risk for malignant neoplasms, including pancreatic ductal adenocarcinoma.

MeSH terms

Adenocarcinoma / genetics*
Adenocarcinoma / therapy
Adult
Aged
Biomarkers, Tumor / genetics*
Carcinoma, Pancreatic Ductal / genetics*
Carcinoma, Pancreatic Ductal / therapy
DNA Mismatch Repair / genetics*
DNA Repair Enzymes / genetics*
DNA Repair-Deficiency Disorders*
DNA-Binding Proteins / genetics
Female
Humans
Male
Middle Aged
Mismatch Repair Endonuclease PMS2 / genetics
MutL Protein Homolog 1 / genetics
MutS Homolog 2 Protein / genetics
Mutation
Retrospective Studies
Survival Analysis

Substances

Biomarkers, Tumor
DNA-Binding Proteins
G-T mismatch-binding protein
MLH1 protein, human
PMS2 protein, human
MSH2 protein, human
Mismatch Repair Endonuclease PMS2
MutL Protein Homolog 1
MutS Homolog 2 Protein
DNA Repair Enzymes