Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f

Sadia Naz; Umar Farooq; Ajmal Khan; Haroon Khan; Nasiara Karim; Rizwana Sarwar; Javid Hussain; Abdur Rauf

doi:10.3389/fphar.2017.00469

Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f

Front Pharmacol. 2017 Jul 25:8:469. doi: 10.3389/fphar.2017.00469. eCollection 2017.

Authors

Sadia Naz¹, Umar Farooq¹, Ajmal Khan^{1

2}, Haroon Khan³, Nasiara Karim⁴, Rizwana Sarwar¹, Javid Hussain⁵, Abdur Rauf⁶

Affiliations

¹ Department of Chemistry, COMSATS Institute of Information TechnologyAbbottabad, Pakistan.
² UoN Chair of Oman Medicinal Plants and Marine Products, University of NizwaNizwa, Oman.
³ Department of Pharmacy, Abdul Wali Khan UniversityMardan, Pakistan.
⁴ Department of Pharmacy, University of MalakandChakdara, Pakistan.
⁵ Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of NizwaNizwa, Oman.
⁶ Department of Chemistry, University of SwabiAmbar, Pakistan.

Abstract

Two new benzyl derivatives were isolated from ethyl acetate fraction of wild strawberry, Fragaria vesca var. nubicola Lindl. ex Hook.f. The structures of these compounds were elucidated to be 5-(4-hydroxy-3-methoxyphenethyl)-7-methoxy-2H-chromen-3-ol (1) and 5-(4-hydroxy-3-methoxyphenethyl)-4,7-dimethoxy-2H-chromen-3-ol (2) based on spectroscopic data through IR, UV, ¹H-NMR, ¹³C-NMR along with two dimensional (2D) techniques HMBC, HMQC, and COSY. Both compounds 1 and 2 were studied in tail suspension and forced swim tests for antidepressant like effects. A significant dose dependent antidepressant like effect was observed by causing spontaneous anti-immobility at various test doses upon intraperitoneal administration.

Keywords: Fragaria vesca var. nubicola; Rosaceae; anti-immobility; antidepressant activity; benzyl derivatives.