Objective: To explore the normal values for two-dimension solid state high resolution anorectal manometry (HRAM) in healthy adult volunteers. Methods: The healthy adult volunteers were recruited by advertisement and underwent solid state HRAM in the left lateral position. Anorectal pressures and rectal sensation were recorded and analyzed. Results: (1) A total of 126 Chinese healthy adult volunteers (male: 50 cases (39.7%); age: (37.5±14.2) years old ) were recruited in this study. (2) Mean anal resting pressure (MERP) was (71.8±17.3) mmHg (1 mmHg=0.133 kPa). Maximum anal resting pressure (MARP) was (79.3±17.8) mmHg, Maximum anal squeeze pressure (MSP) was (178.7±52.8) mmHg. Anal high pressure zone (HPZ) length was (3.4±0.6) cm. During simulated evacuation, residual anal pressure (RAP) was (63.8±20.5) mmHg, and anal relaxation rate (ARR) was (37.0±11.5)%. Rectal threshold volume for first sensation (FST), desire to defecate (DDT), urgency to defecate (UDT) and maximum discomfort (MDT) was (47.4±10.0) ml, (84.5±18.2) ml, (125.8±28.5) ml, and (175.5±36.1) ml, respectively. (3) Compared with female subjects, male subjects had higher MSP[(211.0±50.7) mmHg vs (157.5±42.5) mmHg], RAP[(71.6±18.1) mmHg vs (58.8±20.5) mmHg]and rectal MDT[(187.0±36.4) mmHg vs (168.0±34.1)mmHg], but lower ARR[(32.1±8.0)% vs (40.2±12.3)%], all P<0.01. (4) MERP, MARP, MSP and rectal MDT were higher in young group (≤40 years old), all P<0.05. Conclusions: These observations provide normal values for two-dimension solid state HRAM, which have significant difference between genders and different age groups.
目的： 探讨健康成人2D固态高分辨肛肠测压正常值。 方法： 招募健康成人行固态高分辨肛肠测压，记录分析肛管平均静息压(MERP)、肛管最大静息压(MARP)、肛管最大收缩压(MSP)、肛门括约肌功能(HPZ)长度、模拟排便时肛管残余压(RAP)、直肠肛管压力差(RAPD)、肛门松弛率(ARR)、直肠初始感觉阈值(FST)、初始便意阈值(DDT)、急迫便意阈值(UDT)、最大耐受阈值(MDT)，并探讨性别及年龄的影响。 结果： (1)共纳入126例受试者(男性50例，占39.7%)，年龄18～70(37.5±14.2)岁。(2)MERP (71.8±17.3)mmHg(1 mmHg＝0.133 kPa)，MARP (79.3±17.8)mmHg，MSP (178.7±52.8)mmHg，HPZ长度(3.4±0.6)cm，模拟排便时RAP (63.8±20.5)mmHg，ARR (37.0±11.5)%，DDT (84.5±18.2)ml，UDT (125.8±28.5)ml，MDT (175.5±36.1)ml。(3)与女性相比，男性的MSP[(211.0±50.7)mmHg比(157.5±42.5)mmHg]、RAP[(71.6±18.1)mmHg比(58.8±20.5)mmHg]和直肠MDT[(187.0±36.4)mmHg比(168.0±34.1)mmHg]较高，而ARR较低[(32.1±8.0)%比(40.2±12.3)%]，P均<0.01。(4)与≤40岁受试者比较，>40岁受试者的MERP、MARP、MSP和直肠UDT较低，P均<0.05。 结论： 本研究得到的健康成人固态高分辨肛门直肠测压的检测值可为未来进一步研究国人肛门直肠动力性疾病提供一定依据。研究结果显示，不同年龄、性别人群的肛门直肠功能参数检测值存在一定差异。.
Keywords: High resolution anorectal manometry; Normal values.