A novel fiber curvature sensor without temperature cross interference based on a single hole twin eccentric core fiber has been proposed. Anti-resonant mechanism combined with inline Mach-Zehnder interference (MZI) structure are applied to the measurands detection. The spectrum is composed of a comb spectrum caused by the inline MZI and several dominant resonant wavelengths induced by anti-resonant effect. The curvature sensitivity of -1.54dB/m-1 can be achieved by intensity demodulation of the selected dip of Gaussian fitting. Similarly, the temperature sensitivity of 70.71pm/°C and 34.17pm/°C are respectively achieved by tracking coherent decrease point obtained by the FFT band pass filter method and Gaussian fit dip. Consequently, a relatively higher resolution of temperature measurement can be realized by the two methods mentioned above. The proposed sensor has a great potential for structural health monitoring, such as buildings, towers, bridges, and many other infrastructures due to its compact structure, easy fabrication and without cross impacts.