Abstract
Two new chlorinated fatty acid amides, columbamides D (1) and E (2), along with apratoxins A and C and wewakazole, were isolated from the organic extract of a Moorea bouillonii sample from Sabah, Malaysia. Structure elucidation was accomplished by a combination of MS and NMR analyses. The total synthesis of all four stereoisomers of 1 was completed, and the absolute configuration was determined by chiral-phase HPLC and Marfey's analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry
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Amides / isolation & purification*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Aquatic Organisms
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Cell Line, Tumor
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Cyanobacteria / chemistry*
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Drug Screening Assays, Antitumor / methods
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Fatty Acids / chemistry
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Fatty Acids / isolation & purification*
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Halogenation
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Humans
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Malaysia
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Molecular Conformation
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification
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Stereoisomerism
Substances
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Amides
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Antineoplastic Agents
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Fatty Acids
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Peptides, Cyclic
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wewakazole