Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

Manikantha Maraswami; Sreekumar Pankajakshan; Gang Chen; Teck-Peng Loh

doi:10.1021/acs.orglett.7b01859

Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

Org Lett. 2017 Aug 18;19(16):4223-4226. doi: 10.1021/acs.orglett.7b01859. Epub 2017 Aug 7.

Authors

Manikantha Maraswami¹, Sreekumar Pankajakshan¹, Gang Chen¹, Teck-Peng Loh^{2

1

3}

Affiliations

¹ Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore 637371.
² Institute of Advanced Synthesis, College of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University , Nanjing, Jiangsu 210009, P. R. China.
³ Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.

PMID: 28782962
DOI: 10.1021/acs.orglett.7b01859

Abstract

A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.

Publication types

Research Support, Non-U.S. Gov't