Hair cortisol as a biological marker for burnout symptomatology

Psychoneuroendocrinology. 2018 Jan:87:218-221. doi: 10.1016/j.psyneuen.2017.07.485. Epub 2017 Jul 23.

Abstract

Burnout is a syndrome with negative impact on cognitive performance and mood as a consequence of long-term stress at work. It is further associated with increased risk for mental and physical diseases. One potential pathway to mediate chronic work-stress and adverse health conditions in burnout is through alterations in long-term glucocorticoid secretion. Here, we present cross-sectional data on hair cortisol/cortisone (hairF/hairE) concentrations and burnout from a population-based sample of the Dresden Burnout Study (DBS; N=314 hair samples). Burnout symptoms (emotional exhaustion, cynical attitudes toward work, and reduced efficacy) were assessed with the Maslach Burnout Inventory-General Survey (MBI-GS). To control for potential confounds, depressivity was as well assessed using the Patient Health Questionnaire (PHQ-9) screening instrument for major depression. The present findings indicate specific hypercortisolism in participants who suffer from burnout. No significant associations were found between depressivity and hairF/hairE.

Keywords: Biomarkers; Burnout; Depression; Glucocorticoids; Hair cortisol.

MeSH terms

  • Adult
  • Biomarkers
  • Burnout, Professional / metabolism*
  • Burnout, Professional / physiopathology
  • Cohort Studies
  • Cortisone / analysis
  • Cross-Sectional Studies
  • Depression / metabolism
  • Depressive Disorder, Major / metabolism
  • Emotions / physiology
  • Female
  • Glucocorticoids / analysis
  • Glucocorticoids / metabolism
  • Hair / chemistry*
  • Humans
  • Hydrocortisone / analysis*
  • Hydrocortisone / metabolism
  • Male
  • Middle Aged
  • Stress, Psychological / complications
  • Stress, Psychological / metabolism
  • Surveys and Questionnaires

Substances

  • Biomarkers
  • Glucocorticoids
  • Cortisone
  • Hydrocortisone