Piperidine alkaloids from Alocasia macrorrhiza

Phytochemistry. 2017 Nov:143:81-86. doi: 10.1016/j.phytochem.2017.07.012. Epub 2017 Aug 3.

Abstract

Six previously undescribed piperidine alkaloids were isolated from the rhizomes of Alocasia macrorrhiza (L.) Schott. Their structures were elucidated based on 1D and 2D NMR, IR, HR-ESI-MS spectroscopic analysis and the application of a modified Mosher method. All isolated alkaloids were evaluated for cytotoxicity against five human cancer cell lines (CNE-1, Detroit 562, Fadu, MGC-803, and MCF-7) using the MTT method. Only one compound exhibited cytotoxic effects against Detroit 562, Fadu, and MCF-7 cell lines with IC50 values less than 10 μM.

Keywords: Alkaloids; Alocasia macrorrhiza (L.) Schott; Araceae; Cytotoxicity; Piperidine.

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Alocasia / chemistry*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Humans
  • MCF-7 Cells
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Piperidines / chemistry
  • Piperidines / isolation & purification*
  • Piperidines / pharmacology
  • Rhizome / chemistry

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Piperidines