Colon cancer associated transcripts in human cancers

Yincong Chen; Haibiao Xie; Qunjun Gao; Hengji Zhan; Huizhong Xiao; Yifan Zou; Fuyou Zhang; Yuchen Liu; Jianfa Li

doi:10.1016/j.biopha.2017.07.073

Colon cancer associated transcripts in human cancers

Biomed Pharmacother. 2017 Oct:94:531-540. doi: 10.1016/j.biopha.2017.07.073. Epub 2017 Aug 3.

Authors

Yincong Chen¹, Haibiao Xie², Qunjun Gao³, Hengji Zhan⁴, Huizhong Xiao⁵, Yifan Zou², Fuyou Zhang⁴, Yuchen Liu⁶, Jianfa Li⁷

Affiliations

¹ Shantou University Medical College, Shantou 515041, Guangdong Province, China; Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
² Shantou University Medical College, Shantou 515041, Guangdong Province, China; Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518039, Guangdong Province, China.
³ Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518039, Guangdong Province, China; Guangzhou Medical University, Guangzhou 510182, China.
⁴ Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518039, Guangdong Province, China.
⁵ University of South China, Hengyang, Hunan 421001, China.
⁶ Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518039, Guangdong Province, China. Electronic address: liuyuchenmdcg@163.com.
⁷ Shantou University Medical College, Shantou 515041, Guangdong Province, China; Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518039, Guangdong Province, China; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen 518036, China. Electronic address: lijianfayouxiang@163.com.

PMID: 28779711
DOI: 10.1016/j.biopha.2017.07.073

Abstract

Long non-coding RNAs serve as important regulators in complicated cellular activities, including cell differentiation, proliferation and death. Dysregulation of long non-coding RNAs occurs in the formation and progression of cancers. The family of colon cancer associated transcripts, long non-coding RNAs colon cancer associated transcript-1 and colon cancer associated transcript-2 are known as oncogenes involved in various cancers. Colon cancer associated transcript-1 is a novel lncRNA located in 8q24.2, and colon cancer associated transcript-2 maps to the 8q24.21 region encompassing rs6983267. Colon cancer associated transcripts have close associations with clinical characteristics, such as lymph node metastasis, high TNM stage and short overall survival. Knockdown of them can reverse the malignant phenotypes of cancer cells, including proliferation, migration, invasion and apoptosis. Moreover, they can increase the expression level of c-MYC and oncogenic microRNAs via activating a series of complex mechanisms. In brief, the family of colon cancer associated transcripts may serve as potential biomarkers or therapeutic targets for human cancers.

Keywords: CCAT1; CCAT2; Therapeutic target; c-MYC; lncRNAs.

Publication types

Review

MeSH terms

Humans
Models, Biological
Neoplasms / genetics*
RNA, Long Noncoding / genetics*
RNA, Long Noncoding / metabolism

Substances

RNA, Long Noncoding