Physakengoses K-Q, seven new sucrose esters from Physalis alkekengi var. franchetii

Chuan-Yang Zhang; Jian-Guang Luo; Rui-Huan Liu; Ru Lin; Ming-Hua Yang; Ling-Yi Kong

doi:10.1016/j.carres.2017.07.010

Physakengoses K-Q, seven new sucrose esters from Physalis alkekengi var. franchetii

Carbohydr Res. 2017 Sep 8:449:120-124. doi: 10.1016/j.carres.2017.07.010. Epub 2017 Jul 28.

Authors

Chuan-Yang Zhang¹, Jian-Guang Luo², Rui-Huan Liu¹, Ru Lin¹, Ming-Hua Yang¹, Ling-Yi Kong³

Affiliations

¹ State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, PR China.
² State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address: luojg@cpu.edu.cn.
³ State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address: cpu_lykong@126.com.

PMID: 28779658
DOI: 10.1016/j.carres.2017.07.010

Abstract

Seven sucrose esters, physakengoses K-Q (1-7) were isolated from the aerial parts of Physalis alkekengi var. franchetii. Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical methods. These new compounds were tested for their antimicrobial abilities against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli. Among the isolated sucrose esters, compounds 1-5 showed potent antibacterial activity with MIC values ranging from 2.16 to 12.76 μg/mL.

Keywords: Antibacterial activity; Physalis alkekengi var. franchetii; Solanaceae; Sucrose ester.

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Bacteria / drug effects
Esters / chemistry*
Physalis / chemistry*
Sucrose / chemistry*
Sucrose / pharmacology

Substances

Anti-Bacterial Agents
Esters
Sucrose