How I treat patients with adult onset Still's disease in clinical practice

Marcello Govoni; Alessandra Bortoluzzi; Daniela Rossi; Vittorio Modena

doi:10.1016/j.autrev.2017.07.017

How I treat patients with adult onset Still's disease in clinical practice

Autoimmun Rev. 2017 Oct;16(10):1016-1023. doi: 10.1016/j.autrev.2017.07.017. Epub 2017 Aug 1.

Authors

Marcello Govoni¹, Alessandra Bortoluzzi¹, Daniela Rossi², Vittorio Modena³

Affiliations

¹ Rheumatology Unit, S. Anna Hospital and University of Ferrara, Italy.
² Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases, Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, S. Giovanni Bosco Hospital and University of Turin, Turin, Italy.
³ Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases, Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, S. Giovanni Bosco Hospital and University of Turin, Turin, Italy. Electronic address: modenavittorio@libero.it.

PMID: 28778712
DOI: 10.1016/j.autrev.2017.07.017

Abstract

Adult onset Still's disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by four cardinal signs which are almost always present in patients: high spiking fever, arthralgia (with or without synovitis), maculo-papular salmon-pink evanescent skin rash, striking leukocytosis with neutrophilia. Here, we review the clinical features of AOSD and describe the best practice approaches for its management, reviewing available guidelines and recommendations and providing experts' insights.

Publication types

Review

MeSH terms

Adult
Humans
Still's Disease, Adult-Onset / therapy*