How I treat patients with systemic sclerosis in clinical practice

Daniela Rossi; Elisabetta Zanatta; Piero Marson; Savino Sciascia; Pamela Polito; Dario Roccatello; Franco Cozzi

doi:10.1016/j.autrev.2017.07.018

How I treat patients with systemic sclerosis in clinical practice

Autoimmun Rev. 2017 Oct;16(10):1024-1028. doi: 10.1016/j.autrev.2017.07.018. Epub 2017 Aug 1.

Authors

Daniela Rossi¹, Elisabetta Zanatta², Piero Marson³, Savino Sciascia⁴, Pamela Polito², Dario Roccatello⁴, Franco Cozzi⁵

Affiliations

¹ Center of Research of Immunopathology and Rare Diseases - Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences and University of Turin, Italy; SCU Nephrology and Dialysis Unit, S. Giovanni Bosco Hospital and University of Turin, Turin, Italy. Electronic address: daniela.rossi@unito.it.
² Rheumatology Unit, University Hospital, Padua, Italy.
³ Apheresis Unit, University Hospital, Padua, Italy.
⁴ Center of Research of Immunopathology and Rare Diseases - Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences and University of Turin, Italy; SCU Nephrology and Dialysis Unit, S. Giovanni Bosco Hospital and University of Turin, Turin, Italy.
⁵ Rheumatology Unit, University Hospital, Padua, Italy. Electronic address: franco.cozzi@unipd.it.

PMID: 28778710
DOI: 10.1016/j.autrev.2017.07.018

Abstract

Systemic sclerosis (SSc) or scleroderma is a disorder of the connective tissue affecting the skin, and it is often associated with visceral involvement. The predominant pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. Progressive fibrosis is associated with changes in the microcirculation of the involved organs. Here, we review the clinical features of systemic sclerosis and describe the best practice approaches for its management, reviewing available guidelines and recommendations and providing experts' insights.

Publication types

Review

MeSH terms

Humans
Scleroderma, Systemic / immunology
Scleroderma, Systemic / therapy*