Bronchial thermoplasty induces immunomodulation with a significant increase in pulmonary CD4⁺25⁺ regulatory T cells

Ann Allergy Asthma Immunol. 2017 Sep;119(3):289-290. doi: 10.1016/j.anai.2017.06.019. Epub 2017 Aug 1.

Authors

Mateja Marc Malovrh¹, Aleš Rozman², Sabina Škrgat², Mira Šilar³, Julij Šelb³, Matjaž Fležar², Peter Korošec³

Affiliations

¹ Pulmonology Department, University Clinic for Respiratory and Allergic Diseases, Golnik, Slovenia. Electronic address: mateja.marc@klinika-golnik.si.
² Pulmonology Department, University Clinic for Respiratory and Allergic Diseases, Golnik, Slovenia.
³ Laboratory for Clinical Immunology and Molecular Genetics, University Clinic for Respiratory and Allergic Diseases, Golnik, Slovenia.

PMID: 28778660
DOI: 10.1016/j.anai.2017.06.019

No abstract available

MeSH terms

Adult
Anti-Asthmatic Agents / therapeutic use
Asthma / drug therapy
Asthma / immunology
Asthma / pathology
Asthma / surgery*
Bronchi / drug effects
Bronchi / immunology
Bronchi / pathology
Bronchi / surgery*
Bronchial Thermoplasty / instrumentation
Bronchial Thermoplasty / methods*
Bronchoalveolar Lavage Fluid / cytology
CD4 Antigens / genetics
CD4 Antigens / immunology
Female
Gene Expression
Glucocorticoids / therapeutic use
Humans
Immunomodulation
Immunophenotyping
Interleukin-2 Receptor alpha Subunit / genetics
Interleukin-2 Receptor alpha Subunit / immunology
Male
Middle Aged
T-Lymphocytes, Cytotoxic / immunology*
T-Lymphocytes, Cytotoxic / pathology
T-Lymphocytes, Helper-Inducer / immunology*
T-Lymphocytes, Helper-Inducer / pathology
T-Lymphocytes, Regulatory / immunology*
T-Lymphocytes, Regulatory / pathology

Substances

Anti-Asthmatic Agents
CD4 Antigens
Glucocorticoids
IL2RA protein, human
Interleukin-2 Receptor alpha Subunit