HEXIM1 Has Different Functions within Different RNA-Protein Complexes

Olivier Bensaude

doi:10.1016/j.molcel.2017.07.021

HEXIM1 Has Different Functions within Different RNA-Protein Complexes

Mol Cell. 2017 Aug 3;67(3):357-359. doi: 10.1016/j.molcel.2017.07.021.

Author

Olivier Bensaude¹

Affiliation

¹ IBENS-CNRS UMR 8197-INSERM U1024-Ecole Normale Supérieure 46, Rue d'Ulm, Cedex 05, 75230 Paris, France. Electronic address: bensaude@biologie.ens.fr.

PMID: 28777948
DOI: 10.1016/j.molcel.2017.07.021

Abstract

In this issue of Molecular Cell, Morchikh et al. (2017) describe a new ribonuclear complex built around HEXIM1 and the long non-coding RNA NEAT1. This complex regulates the innate immune response to DNA viruses and is distinct from the HEXIM1-7SK RNA complex that regulates transcription elongation.

MeSH terms

HeLa Cells
Humans
Positive Transcriptional Elongation Factor B / genetics*
RNA, Long Noncoding
RNA, Small Nuclear / genetics
RNA-Binding Proteins / genetics*

Substances

RNA, Long Noncoding
RNA, Small Nuclear
RNA-Binding Proteins
Positive Transcriptional Elongation Factor B