SAPHO and Recurrent Multifocal Osteomyelitis

Simon Greenwood; Antonio Leone; Victor N Cassar-Pullicino

doi:10.1016/j.rcl.2017.04.009

SAPHO and Recurrent Multifocal Osteomyelitis

Radiol Clin North Am. 2017 Sep;55(5):1035-1053. doi: 10.1016/j.rcl.2017.04.009.

Authors

Simon Greenwood¹, Antonio Leone², Victor N Cassar-Pullicino³

Affiliations

¹ Department of Diagnostic Imaging, The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Twmpath Lane, Gobowen, Oswestry SY10 7AG, UK.
² Emergency/Musculoskeletal Section, Institute of Radiology, Catholic University, School of Medicine, Policlinico A. Gemelli, Largo A. Gemelli, 1, Rome 00135, Italy.
³ Department of Diagnostic Imaging, The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Twmpath Lane, Gobowen, Oswestry SY10 7AG, UK. Electronic address: victor.pullicino@rjah.nhs.uk.

PMID: 28774447
DOI: 10.1016/j.rcl.2017.04.009

Abstract

SAPHO and recurrent multifocal osteomyelitis are complex inflammatory conditions that clinical radiologists play an essential part in diagnosing. They present with a wide range of musculoskeletal and skin manifestations, and exhibit several key diagnostic features that, when present, make the diagnoses unequivocal. The overall population group is young. Diagnostic delay is common with a relapsing and remitting clinical course and often subtle early radiologic findings. This article provides an up-to-date insight into both conditions, including their multifaceted pathogenesis, effective therapeutic options, and advanced imaging features, to arm radiologists with the knowledge required to make the diagnoses confidently in a timely manner.

Keywords: CRMO; Hyperostosis; Osteitis; Pediatric; SAPHO; Whole-body MR imaging.

Publication types

Review

MeSH terms

Acquired Hyperostosis Syndrome / diagnostic imaging*
Humans
Magnetic Resonance Imaging / methods*
Osteomyelitis / diagnostic imaging*
Radiography / methods*

Supplementary concepts

Chronic recurrent multifocal osteomyelitis