Primary CD30-positive Diffuse Large B-cell Lymphoma in the Superior Vena Cava

Intern Med. 2017;56(15):2043-2047. doi: 10.2169/internalmedicine.56.8203. Epub 2017 Aug 1.

Abstract

Primary superior vena cava lymphoma originating from the endothelium of a large vein is very rare. A 70-year-old man was admitted to the hospital; computed tomography showed a tumor limited to the inside of the superior vena cava, completely occluding the vessel. A transjugular biopsy confirmed the diagnosis of diffuse large B-cell lymphoma, which was diffusely positive for CD30. Rituximab monotherapy followed by five courses of R-CHOP chemotherapy induced a complete remission. There was no recurrence after two years. The pathophysiology of lymphoma derived from large vessels may be different from intravascular large B-cell lymphoma, which usually involves small vessels.

Keywords: CD30; intravascular lymphoma; malignant lymphoma; superior vena cava syndrome.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Monoclonal, Murine-Derived / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biopsy
  • Cyclophosphamide / therapeutic use
  • Doxorubicin / therapeutic use
  • Humans
  • Ki-1 Antigen / analysis
  • Lymphoma, Large B-Cell, Diffuse / complications
  • Lymphoma, Large B-Cell, Diffuse / diagnostic imaging*
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Male
  • Neoplasm Recurrence, Local / drug therapy
  • Prednisone / therapeutic use
  • Remission Induction
  • Rituximab
  • Superior Vena Cava Syndrome / etiology
  • Tomography, X-Ray Computed
  • Vena Cava, Superior*
  • Vincristine / therapeutic use

Substances

  • Antibodies, Monoclonal, Murine-Derived
  • Ki-1 Antigen
  • R-CHOP protocol
  • Rituximab
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone