Holding Onto Youth

Alain Dagher; Bratislav Misic

doi:10.1016/j.cmet.2017.07.015

Holding Onto Youth

Cell Metab. 2017 Aug 1;26(2):284-285. doi: 10.1016/j.cmet.2017.07.015.

Authors

Alain Dagher¹, Bratislav Misic²

Affiliations

¹ Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada. Electronic address: alain.dagher@mcgill.ca.
² Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.

PMID: 28768166
DOI: 10.1016/j.cmet.2017.07.015

Abstract

Aerobic glycolysis (AG), the synthesis of lactate despite the presence of oxygen, has been implicated in the growth of cancer cells, synaptic development, and brain plasticity. In this issue of Cell Metabolism, Goyal et al. (2017) demonstrate that AG declines with age in the human brain, disappearing almost completely by age 60.

Publication types

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MeSH terms

Brain*
Citric Acid Cycle
Glycolysis*
Humans
Lactic Acid

Substances

Lactic Acid