Six-Month Response to Delamanid Treatment in MDR TB Patients

Emerg Infect Dis. 2017 Oct;23(10):1746-1748. doi: 10.3201/eid2310.170468. Epub 2017 Oct 17.

Abstract

Delamanid, recently available for the treatment of multidrug-resistant tuberculosis (MDR TB), has had limited use outside clinical trials. We present the early treatment results for 53 patients from 7 countries who received a delamanid-containing treatment for MDR TB. Results show good tolerability and treatment response at 6 months.

Keywords: Armenia; Belarus; Georgia; India; MDR TB; Russia; South Africa; Swaziland; Tuberculosis; antimicrobial resistance; antitubercular agents; bacteria; combination; delamanid; drug therapy; multidrug resistance.

MeSH terms

  • Adolescent
  • Antitubercular Agents / therapeutic use*
  • Female
  • HIV Infections / complications
  • Hepatitis C / complications
  • Humans
  • Male
  • Nitroimidazoles / therapeutic use*
  • Oxazoles / therapeutic use*
  • Retrospective Studies
  • Tuberculosis, Multidrug-Resistant / complications
  • Tuberculosis, Multidrug-Resistant / drug therapy*

Substances

  • Antitubercular Agents
  • Nitroimidazoles
  • OPC-67683
  • Oxazoles