Imaging assessment of bioresorbable vascular scaffolds

Cardiovasc Interv Ther. 2018 Jan;33(1):11-22. doi: 10.1007/s12928-017-0486-5. Epub 2017 Aug 1.

Abstract

Vascular reparative therapy has become a reality with bioresorbable scaffolds (BRSs). To assess acute and long-term performance of the device, multimodality imaging would be essential. Radiopacity of metal hinders the imaging assessment, whereas radiolucent polymeric scaffolds allow for a precise imaging assessment with either invasive or non-invasive modality at baseline and at follow-up, which is one of the advantages of polymeric BRSs. Recent large trials evaluating clinical results of the first-generation BRS technology raised concerns about the safety and efficacy of these devices, namely, scaffold thrombosis. Intensive research with multimodality imaging in the field is being conducted to have in-depth understanding of the issues, which will facilitate the improvement of implantation techniques and the development of the next-generation BRSs. The current review focuses on the clinical application of the imaging modalities to assess the short- and long-term performance of the Absorb BVS.

Keywords: Bioresorbable scaffold; Imaging.

Publication types

  • Review

MeSH terms

  • Absorbable Implants*
  • Coronary Artery Disease / diagnostic imaging*
  • Coronary Artery Disease / physiopathology
  • Coronary Artery Disease / therapy*
  • Drug-Eluting Stents
  • Everolimus / administration & dosage
  • Guided Tissue Regeneration
  • Humans
  • Multimodal Imaging
  • Percutaneous Coronary Intervention
  • Polyesters / administration & dosage
  • Prosthesis Design
  • Tissue Scaffolds*
  • Wound Healing / physiology

Substances

  • Polyesters
  • poly(lactide)
  • Everolimus