Rakicidin F, a new antibacterial cyclic depsipeptide from a marine sponge-derived Streptomyces sp

Shigeru Kitani; Tatsuya Ueguchi; Yasuhiro Igarashi; Kantinan Leetanasaksakul; Arinthip Thamchaipenet; Takuya Nihira

doi:10.1038/ja.2017.92

Rakicidin F, a new antibacterial cyclic depsipeptide from a marine sponge-derived Streptomyces sp

J Antibiot (Tokyo). 2017 Aug 2. doi: 10.1038/ja.2017.92. Online ahead of print.

Authors

Shigeru Kitani¹, Tatsuya Ueguchi¹, Yasuhiro Igarashi², Kantinan Leetanasaksakul^{3

4}, Arinthip Thamchaipenet³, Takuya Nihira^{1

5}

Affiliations

¹ International Center for Biotechnology, Osaka University, Osaka, Japan.
² Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
³ Department of Genetics, Faculty of Science, Kasetsart University, Bangkok, Thailand.
⁴ Interdisciplinary Graduate Program in Genetic Engineering, Graduate School, Kasetsart University, Bangkok, Thailand.
⁵ MU-OU Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand.

PMID: 28765588
DOI: 10.1038/ja.2017.92

Abstract

A new cyclic depsipeptide, rakicidin F (1), along with the known compound rakicidin C (2), was isolated from the fermentation broth of the marine sponge-derived actinomycete strain Streptomyces sp. GKU 220. Their structures were elucidated by interpreting the HRFABMS and NMR spectroscopic data. Rakicidin F (1) showed growth inhibitory activity against bacteria.The Journal of Antibiotics advance online publication, 2 August 2017; doi:10.1038/ja.2017.92.