TRPs and Ca2+ in cell death and survival

Ingrid Fliniaux; Emmanuelle Germain; Valerio Farfariello; Natalia Prevarskaya

doi:10.1016/j.ceca.2017.07.002

TRPs and Ca²⁺ in cell death and survival

Cell Calcium. 2018 Jan:69:4-18. doi: 10.1016/j.ceca.2017.07.002. Epub 2017 Jul 15.

Authors

Ingrid Fliniaux¹, Emmanuelle Germain¹, Valerio Farfariello¹, Natalia Prevarskaya²

Affiliations

¹ Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Equipe Labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université de Lille 1-Sciences et Technologies, Villeneuve d'Ascq 59656, France.
² Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Equipe Labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université de Lille 1-Sciences et Technologies, Villeneuve d'Ascq 59656, France. Electronic address: natacha.prevarskaya@univ-lille1.fr.

PMID: 28760561
DOI: 10.1016/j.ceca.2017.07.002

Abstract

Transient Receptor Potential (TRP) family mediate the influx of monovalent and/or divalent cations into cells in response to environmental stimuli. Pharmacological or genetic manipulations of TRP channels demonstrate that TRP channels influence cell death rates, prolonging or shortening of cell survival. Due to their diverse cellular localization, TRP channels mediated Ca²⁺ influx generates distinct intracellular Ca²⁺ signals that regulate downstream pathways converging to apoptosis or survival. In this review, we summarize the accumulated knowledge focused on how TRP channel regulate cell fate and may affect different pathologies including cardiovascular, neurological, metabolic or neoplastic disorders.

Keywords: Apoptosis; Autophagy; Cell death; Survival; TRP channels.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Calcium / metabolism*
Cell Death
Cell Survival
Humans
Transient Receptor Potential Channels / metabolism*

Substances

Transient Receptor Potential Channels
Calcium