miRNAs in B-cell lymphoma: Molecular mechanisms and biomarker potential

Carla Solé; Erika Larrea; Giovanni Di Pinto; Maitena Tellaetxe; Charles Henderson Lawrie

doi:10.1016/j.canlet.2017.07.020

miRNAs in B-cell lymphoma: Molecular mechanisms and biomarker potential

Cancer Lett. 2017 Oct 1:405:79-89. doi: 10.1016/j.canlet.2017.07.020. Epub 2017 Jul 27.

Authors

Carla Solé¹, Erika Larrea¹, Giovanni Di Pinto¹, Maitena Tellaetxe¹, Charles Henderson Lawrie²

Affiliations

¹ Molecular Oncology Group, Biodonostia Research Institute, San Sebastián, Gipuzkoa, Spain.
² Molecular Oncology Group, Biodonostia Research Institute, San Sebastián, Gipuzkoa, Spain; Radcliffe Department of Medicine, University of Oxford, Oxford, UK; IKERBASQUE, Basque Foundation for Science, Bilbao, Bizkaia, Spain. Electronic address: charles.lawrie@biodonostia.org.

PMID: 28757417
DOI: 10.1016/j.canlet.2017.07.020

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that regulate many human genes including those involved in normal B-cell development. When these miRNAs are aberrantly expressed in B-cells they play key pathogenetic roles in the development and maintenance of B-cell lymphomas and by association may serve as useful biomarkers. In this review, we provide an overview of the importance of miRNAs to B-cell lymphomagenesis, as well as considering their use as biomarkers, and their potential usefulness for the clinic.

Keywords: B-cell lymphoma; Biomarker; Hodgkin lymphoma; Lymphoma; MicroRNA; Non-Hodgkin lymphoma.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor* / genetics
Biomarkers, Tumor* / metabolism
Gene Expression Regulation, Neoplastic*
Humans
Lymphoma, B-Cell / diagnosis*
Lymphoma, B-Cell / genetics*
Lymphoma, B-Cell / pathology
MicroRNAs* / genetics
MicroRNAs* / metabolism

Substances

Biomarkers, Tumor
MicroRNAs