Synthesis and antioxidant ability of 6,6'-diamino-6,6'-dideoxytrehalose

Bioorg Chem. 2017 Oct:74:66-71. doi: 10.1016/j.bioorg.2017.07.005. Epub 2017 Jul 20.

Abstract

In order to study the influence of amino group on antioxidant activity of oligosaccharides, an amino disaccharide, 6,6'-diamino-6,6'-dideoxytrehalose (DAMDT) was successfully prepared in this paper, and its antioxidant activities against DPPH, superoxide, hydrogen peroxide, and hydroxyl radicals, and reducing power were evaluated, respectively. The results indicated that DAMDT had better antioxidant activity than trehalose at any tested concentration. The influence of amino group on antioxidant activity of disaccharides is positive based on the results in this paper, and amination should be an effective method to improve the bioactivity of saccharides.

Keywords: 6,6′-Diamino-6,6′-dideoxytrehalose; Antioxidant activity; Trehalose.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemical synthesis
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Biphenyl Compounds / antagonists & inhibitors
  • Hydrogen Peroxide / antagonists & inhibitors
  • Hydroxyl Radical / antagonists & inhibitors
  • Picrates / antagonists & inhibitors
  • Superoxides / antagonists & inhibitors
  • Trehalose / analogs & derivatives*
  • Trehalose / chemical synthesis
  • Trehalose / chemistry
  • Trehalose / pharmacology

Substances

  • 6,6'-diamino-6,6'-dideoxytrehalose
  • Antioxidants
  • Biphenyl Compounds
  • Picrates
  • Superoxides
  • Hydroxyl Radical
  • Trehalose
  • Hydrogen Peroxide
  • 1,1-diphenyl-2-picrylhydrazyl