Successful use of digoxin-specific immune Fab in the treatment of severe Nerium oleander toxicosis in a dog

J Vet Emerg Crit Care (San Antonio). 2017 Sep;27(5):596-604. doi: 10.1111/vec.12634. Epub 2017 Jul 29.

Abstract

Objective: To describe a case in which digoxin-specific immune Fab was used successfully in a dog with severe oleander toxicosis secondary to ingesting plant material.

Case summary: A 6-year-old intact female Rhodesian Ridgeback mixed breed dog was presented for severe oleander toxicosis and was refractory to all antiarrhythmic therapies and supportive care. Digoxin-specific immune Fab was successful in treating this dog. The dog recovered but suffered ischemic injuries, the long-term effects of which are unknown.

New or unique information provided: This report describes the successful use of digoxin-specific immune Fab in the treatment of oleander toxicosis in a dog, which has not previously been published in veterinary literature. Oleander poisoning can be associated with permanent cardiac arrhythmias due to the ischemic damage.

Keywords: antidote; arrhythmias; poisonous plant; toxicology.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Anti-Arrhythmia Agents / therapeutic use*
  • Antibodies, Blocking
  • Arrhythmias, Cardiac / chemically induced
  • Arrhythmias, Cardiac / complications
  • Arrhythmias, Cardiac / veterinary*
  • Digoxin / immunology
  • Dogs
  • Female
  • Immunoglobulin Fab Fragments / immunology*
  • Nerium / toxicity*
  • Plant Poisoning / drug therapy
  • Plant Poisoning / veterinary*

Substances

  • Anti-Arrhythmia Agents
  • Antibodies, Blocking
  • Immunoglobulin Fab Fragments
  • digoxin antibodies Fab fragments
  • Digoxin