Benzophenone glycosides from the flower buds of Aquilaria sinensis

Fitoterapia. 2017 Sep:121:170-174. doi: 10.1016/j.fitote.2017.07.013. Epub 2017 Jul 25.

Abstract

Four new benzophenone glycosides named as aquilaside A-D (1-4) along with five known compounds (5-9) were isolated from the methanol extract of the flower buds of Aquilaria sinensis. Their structures were elucidated on the basis of 1D and 2D NMR and mass spectroscopic analyses. All purified compounds were evaluated for their anti-inflammatory and cytotoxic activities. Aquilasides B and C displayed moderate cytotoxicity against SK-MEL cells with IC50 of 17.0 and 12.0μM and weak NF-κB inhibitive activity at 100μM with 30% and 60%, respectively.

Keywords: Aquilaria sinensis; Benzophenone glycosides; NMR; Structure elucidation; Thymelaeaceae.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Benzophenones / chemistry*
  • Benzophenones / isolation & purification
  • Cell Line, Tumor
  • Flowers / chemistry*
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Humans
  • Mice
  • Molecular Structure
  • NF-kappa B / antagonists & inhibitors
  • Nitric Oxide Synthase Type II / antagonists & inhibitors
  • Oxidative Stress / drug effects
  • Plant Extracts / chemistry
  • RAW 264.7 Cells
  • Thymelaeaceae / chemistry*

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents, Phytogenic
  • Benzophenones
  • Glycosides
  • NF-kappa B
  • Plant Extracts
  • Nitric Oxide Synthase Type II
  • Nos2 protein, mouse