Abstract
Three types, esters, amides and 1,2,3-triazoles, of ferrocenyl-podophyllotoxin conjugates were synthesised, and their anticancer activity was evaluated. We observed that the most potent ferrocenyl derivatives were esters. Esters 15, 16 and 17 acted in a similar way to podophyllotoxin, i.e. reduced the number of G1 phase cells and induced G2/M blockage, while esters 14 and 18 and amide 19 blocked cells in S phase in a similar manner to etoposide.
MeSH terms
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Amides / chemistry
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology*
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Cell Cycle / drug effects
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Cell Line, Tumor
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Chemistry Techniques, Synthetic
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Esterases / metabolism
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Ferrous Compounds / chemistry*
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Humans
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Metallocenes / chemistry*
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Models, Molecular
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Molecular Conformation
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Podophyllotoxin / chemical synthesis*
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Podophyllotoxin / chemistry
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Podophyllotoxin / metabolism
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Podophyllotoxin / pharmacology*
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Protein Multimerization / drug effects
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Protein Structure, Quaternary
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Triazoles / chemistry
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Tubulin / chemistry
Substances
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Amides
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Antineoplastic Agents
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Ferrous Compounds
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Metallocenes
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Triazoles
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Tubulin
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Esterases
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Podophyllotoxin
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ferrocene