Neuro-ophthalmological findings in TAFRO syndrome in a patient from South America, a variant of multicentric Castleman's disease

Int Ophthalmol. 2018 Aug;38(4):1641-1646. doi: 10.1007/s10792-017-0636-x. Epub 2017 Jul 27.

Abstract

Background: To report the neuro-ophthalmological findings in the TAFRO syndrome in a South American patient.

Methods: This is a case report of a patient with TAFRO syndrome.

Results: We present the case of a 66-year-old woman with TAFRO syndrome and multicentric Castleman disease, who developed ophthalmic manifestations, as a rare complication, including optic disk edema and serous retinal detachment, which improved with conventional therapy.

Conclusions: The optic disk edema could be present as a neuro-ophthalmological finding in TAFRO syndrome. To the best of our knowledge, this is the first report on the ophthalmic manifestations in the TAFRO syndrome.

Keywords: Electrophysiology; Multicentric Castleman’s disease; Optic nerve disease; Thrombocytopenia.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Castleman Disease / pathology*
  • Electroretinography
  • Epiretinal Membrane / pathology*
  • Female
  • Humans
  • Papilledema / pathology*
  • Retinal Detachment / pathology*
  • Retinal Ganglion Cells / physiology*
  • South America

Supplementary concepts

  • Multi-centric Castleman's Disease