Wound redox gradients revisited

Semin Cell Dev Biol. 2018 Aug:80:13-16. doi: 10.1016/j.semcdb.2017.07.038. Epub 2017 Jul 24.

Abstract

Evidence emerges that redox gradients regulate morphogenesis, inflammation, regeneration, and healing of tissues. At the example of redox signaling during the zebrafish wound response, I briefly discuss current ideas on how such patterns might be sensed and spatially regulated to guide physiological processes over distances in animals.

Keywords: Biosensor; Chemotaxis; Imaging; Metabolic gradient; NADPH oxidase; Neutrophil; Reactive oxygen species; Redox gradient; Signaling; Wound healing; Zebrafish.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Inflammation / metabolism*
  • Oxidation-Reduction*
  • Reactive Oxygen Species / metabolism*
  • Signal Transduction / physiology
  • Wound Healing / physiology*

Substances

  • Reactive Oxygen Species