FISH Analysis of Crizotinib Target Genes ROS1/ALK/MET in Malignant Mesothelioma

J Thorac Oncol. 2017 Aug;12(8):e116-e118. doi: 10.1016/j.jtho.2017.03.015.

Authors

Sandra Salvi¹, Serena Varesano¹, Simona Boccardo¹, Jean Louis Ravetti¹, Pier Aldo Canessa², Maria Pia Pistillo³, Paola Ferro⁴, Franco Fedeli⁴, Silvio Roncella⁵

Affiliations

¹ Division of Histopathology and Cytopathology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
² Division of Pneumology, Azienda Sanitaria Locale Number 5, La Spezia, Italy.
³ Unit of Tumor Epigenetics, IRCCS AOU San Martino-IST, Genoa, Italy.
⁴ Division of Histopathology and Cytopathology, Azienda Sanitaria Locale Number 5, La Spezia, Italy.
⁵ Division of Histopathology and Cytopathology, Azienda Sanitaria Locale Number 5, La Spezia, Italy. Electronic address: silvio.roncella@asl5.liguria.it.

PMID: 28748818
DOI: 10.1016/j.jtho.2017.03.015

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Crizotinib
Humans
In Situ Hybridization, Fluorescence / methods*
Lung Neoplasms / genetics*
Lung Neoplasms / metabolism*
Mesothelioma / genetics*
Mesothelioma / metabolism*
Mesothelioma, Malignant
Protein Kinase Inhibitors / pharmacology
Protein Kinase Inhibitors / therapeutic use*
Protein-Tyrosine Kinases / genetics*
Proto-Oncogene Proteins / genetics*
Pyrazoles / pharmacology
Pyrazoles / therapeutic use*
Pyridines / pharmacology
Pyridines / therapeutic use*
Receptor Protein-Tyrosine Kinases / genetics*

Substances

Protein Kinase Inhibitors
Proto-Oncogene Proteins
Pyrazoles
Pyridines
Crizotinib
Protein-Tyrosine Kinases
ROS1 protein, human
Receptor Protein-Tyrosine Kinases