Long-term efficient control of SIV infection in macaques is associated with an intact intestinal barrier

J Med Primatol. 2017 Aug;46(4):144-148. doi: 10.1111/jmp.12294.

Abstract

Hallmarks of SIV infection are early depletion of gut CD4 T cells and diminished intestinal integrity. Comprehensive studies on colon biopsies of SIV-infected macaques efficiently controlling infection revealed that in contrast to viremic and failing controllers, elite controllers show preserved CD4 T cells, and low viral load, apoptosis, and inflammation.

Keywords: CD4 depletion; apoptosis; colon; immune activation; microbial translocation; simian immunodeficiency virus.

MeSH terms

  • Animals
  • Apoptosis
  • CD4 Lymphocyte Count
  • Colon / anatomy & histology
  • Colon / immunology*
  • Colon / virology
  • India
  • Macaca mulatta*
  • Simian Acquired Immunodeficiency Syndrome / immunology*
  • Simian Acquired Immunodeficiency Syndrome / virology
  • Simian Immunodeficiency Virus / physiology