Abstract
Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 70 aIIa U/kg non-fractionated heparin shortened plasma clotting time (shown by partial activated thromboplastin time, thrombin time, and prothrombin time). Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 1 mg/kg (100 aXa U/kg) low-molecular-weight heparin (clexane) led to shortening of plasma clotting time in the ReaClot Heparin test and to prolongation of plasma amidolytic activity in the factor Xa chromogenic substrate test.
Keywords:
anticoagulant activity; guinea pigs; heparin; protamine sulfate; quarternized chitosan derivative.
MeSH terms
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Animals
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Anticoagulants / pharmacokinetics*
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Anticoagulants / pharmacology
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Antidotes / chemical synthesis
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Antidotes / pharmacokinetics*
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Antidotes / pharmacology
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Chitosan / chemical synthesis
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Chitosan / pharmacokinetics*
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Chitosan / pharmacology
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Female
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Guinea Pigs
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Heparin / pharmacokinetics*
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Heparin / pharmacology
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Heparin, Low-Molecular-Weight / pharmacokinetics*
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Heparin, Low-Molecular-Weight / pharmacology
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Injections, Intravenous
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Partial Thromboplastin Time
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Protamines / chemical synthesis
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Protamines / pharmacokinetics
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Protamines / pharmacology
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Prothrombin Time
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Quaternary Ammonium Compounds / chemical synthesis
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Quaternary Ammonium Compounds / pharmacokinetics*
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Quaternary Ammonium Compounds / pharmacology
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Thrombin Time
Substances
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Anticoagulants
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Antidotes
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Heparin, Low-Molecular-Weight
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Protamines
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Quaternary Ammonium Compounds
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Heparin
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Chitosan