Serotonin and dopamine as regulators of adenylate cyclase and relaxation in a smooth muscle of the mussel Mytilus edulis

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;84(1):61-6. doi: 10.1016/0742-8413(86)90165-9.

Abstract

Serotonin and dopamine show similar dose-response relationships when they relax tonically contracted intact muscle fibres of the anterior byssus retractor muscle of Mytilus edulis. In saponin-treated muscle fibers, only serotonin or high doses of dopamine relax tonic contraction. In a membrane fraction, enriched in adenylate cyclase activity, serotonin and dopamine increase the rate of cAMP production. Serotonin is a far more potent activator of adenylate cyclase than dopamine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenylyl Cyclases / metabolism*
  • Animals
  • Bivalvia / physiology
  • Dopamine / pharmacology*
  • In Vitro Techniques
  • Kinetics
  • Muscle Contraction / drug effects*
  • Muscle Relaxation / drug effects*
  • Muscle, Smooth / drug effects
  • Muscle, Smooth / physiology*
  • Serotonin / pharmacology*

Substances

  • Serotonin
  • Adenylyl Cyclases
  • Dopamine