Objective: To analyze transmission factors of norovirus outbreaks in Guangdong province during 2008-2015 and provide evidence for the prevention and control of norovirus infection. Methods: Epidemiological analysis was performed on the data of norovirus outbreaks reported in Guangdong from January 1, 2008 to December 31, 2015, which were obtained from the Public Health Emergency Management Information System of Guangdong province. The samples collected from the norovirus outbreaks were detected for norovirus by RT-PCR and the gene sequencing of the positive PCR products were performed. Results: A total of 96 norovirus outbreaks were reported in Guangdong during 2008-2015. Sixteen outbreaks were reported during 2008-2012 and 80 outbreaks were reported during 2013-2015 (83.3%). Eighty-two outbreaks (85.4%) occurred in schools. The infection routes included foodborne transmission in 39 outbreaks (40.6%), person to person transmission in 23 outbreaks (24.0%) and waterborne transmission in 8 outbreaks (7.3%). The gene sequencing results showed that variant GⅡ.4/Sydney2012 was the predominant pathogen for 6 of the 20 outbreaks (30.0%) during 2012-2013. Variant GⅡ.17 was the predominant pathogens for 33 of the 53 outbreaks (62.3%) during 2014-2015. Conclusion: The norovirus outbreaks in Guangdong during 2008-2015 were caused by foodborne and person to person transmissions of two emerging variant: GⅡ.4/Sydney2012 and GⅡ.17.
目的： 研究2008－2015年广东省诺如病毒感染暴发疫情的危险因素，为诺如病毒感染的预防控制工作提供参考依据。 方法： 通过"突发公共卫生事件报告管理信息系统"收集2008年1月1日至2015年12月31日广东省报告的诺如病毒感染暴发疫情资料，并进行流行病学分析。采用RT-PCR方法对2012－2015年73起诺如病毒感染暴发疫情的372份阳性标本进行基因测序亚型分析。 结果： 2008－2015年广东省共报告96起诺如病毒感染暴发疫情，其中2013－2015年共报告80起（占83.3%，80/96）。暴发地点在学校的占全部疫情的85.4%（82/96）；传播途径为食源性传播占40.6%（39/96），接触传播占24.0%（23/96），水源性传播占7.3%（8/96）。基因测序亚型分析显示，2012－2013年的暴发主要由GⅡ.4/Sydney2012型诺如病毒感染引起（占30.0%，6/20），2014－2015年的暴发主要由GⅡ.17型诺如病毒感染引起（占62.3%，33/53）。 结论： 食源性和接触传播及新出现的2种诺如病毒变异株GⅡ.4/Sydney2012变异株和GⅡ.17是引起广东省诺如病毒感染暴发的主要原因。.
Keywords: Epidemiology; Genotype; Norovirus; Outbreaks.