Mass spectrometric techniques for the analysis of volatile organic compounds emitted from bacteria

Bioanalysis. 2017 Jul;9(14):1069-1092. doi: 10.4155/bio-2017-0051. Epub 2017 Jul 24.

Abstract

Bacteria are the main cause of many human diseases. Typical bacterial identification methods, for example culture-based, serological and genetic methods, are time-consuming, delaying the potential for an early and accurate diagnosis and the appropriate subsequent treatment. Nevertheless, there is a stringent need for in situ tests that are rapid, noninvasive and sensitive, which will greatly facilitate timely treatment of the patients. This review article presents volatile organic metabolites emitted from various micro-organism strains responsible for common bacterial infections in humans. Additionally, the manuscript shows the application of different analytical techniques for fast bacterial identification. Details of these techniques are given, which focuses on their advantages and drawbacks in using for volatile organic components analysis.

Keywords: bacterial markers; early diagnosis; highly desired tools; hyphenated techniques; screening and quantification.

Publication types

  • Review

MeSH terms

  • Bacteria / metabolism*
  • Biomarkers / analysis
  • Biomarkers / chemistry
  • Biomarkers / metabolism
  • Humans
  • Mass Spectrometry / instrumentation
  • Mass Spectrometry / methods*
  • Translational Research, Biomedical
  • Volatile Organic Compounds / analysis*
  • Volatile Organic Compounds / chemistry
  • Volatile Organic Compounds / metabolism

Substances

  • Biomarkers
  • Volatile Organic Compounds