miRNA meets plasma cells "How tiny RNAs control antibody responses"

Julia Meinzinger; Hans-Martin Jäck; Katharina Pracht

doi:10.1016/j.clim.2017.07.015

miRNA meets plasma cells "How tiny RNAs control antibody responses"

Clin Immunol. 2018 Jan:186:3-8. doi: 10.1016/j.clim.2017.07.015. Epub 2017 Jul 21.

Authors

Julia Meinzinger¹, Hans-Martin Jäck², Katharina Pracht¹

Affiliations

¹ Division of Molecular Immunology, Internal Medicine III, Nikolaus-Fiebiger-Center of MolecularMedicine, University Hospital Erlangen, Erlangen, Germany.
² Division of Molecular Immunology, Internal Medicine III, Nikolaus-Fiebiger-Center of MolecularMedicine, University Hospital Erlangen, Erlangen, Germany. Electronic address: hans-martin.jaeck@fau.de.

PMID: 28736279
DOI: 10.1016/j.clim.2017.07.015

Abstract

We review the importance of small non-coding microRNAs for the generation of germinal center B cells and their differentiation in antibody-secreting plasma cells. In the last part, we briefly elucidate the role of microRNAs in some plasma cell disorders.

Keywords: Germinal center; Multiple myeloma; Plasma cell; RA; SLE; miRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antibody Formation*
Autoimmunity
Cell Differentiation
Germinal Center / immunology
Humans
Immune System Diseases / immunology
MicroRNAs*
Plasma Cells / immunology*

Substances

MicroRNAs