Abstract
Auranofin in the mucosal fluid caused a dose-dependent inhibition of fluid and Na+ absorption by everted sacs of rat colon. Serosal auranofin was without effect. (Na+ + K+)ATPase activity of homogenates of mucosal scrapes of rat colon was inhibited by auranofin in a dose-related manner, while Mg2+-ATPase activity was little affected. These actions of the drug on colonic transport mechanisms could contribute to the diarrhoea associated with auranofin therapy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphatases / metabolism
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Animals
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Anti-Inflammatory Agents / pharmacology*
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Auranofin
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Aurothioglucose / analogs & derivatives*
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Aurothioglucose / pharmacology
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Biological Transport / drug effects
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Colon / metabolism*
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Gold / analogs & derivatives*
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Intestinal Mucosa / enzymology
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Male
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Rats
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Sodium / metabolism*
Substances
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Anti-Inflammatory Agents
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Aurothioglucose
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Auranofin
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Gold
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Sodium
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Adenosine Triphosphatases