Abstract
The present review aimed to assess the networks of transcription factors regulating the Oct4 expression in mice. Through a comprehensive analysis of the binding sites and the interrelationships of the transcription factors of Oct4, it is found that transcription factors of Oct4 form three regulating complexes centered by Oct4-Sox2, Nanog, and Lrh1. They bind on CR4, CR2, and CR1 regions of Oct4 promoter/enhancer, respectively, to activate Oct4 transcription synergistically. This article also discusses the mechanisms of fine-tuning the Oct4 expression. These findings have important implications in the field of stem cell and developmental biology.
Keywords:
Lrh1; Nanog; Oct4; Oct4 expression; Sox2; mice.
MeSH terms
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Animals
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Cell Hypoxia / physiology
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Embryonic Stem Cells / metabolism
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism
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Mice
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Nanog Homeobox Protein / genetics
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Nanog Homeobox Protein / metabolism
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Octamer Transcription Factor-3 / genetics*
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Octamer Transcription Factor-3 / metabolism*
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Promoter Regions, Genetic
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Receptors, Cytoplasmic and Nuclear / genetics
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Receptors, Cytoplasmic and Nuclear / metabolism
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SOXB1 Transcription Factors / genetics
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SOXB1 Transcription Factors / metabolism
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Sp1 Transcription Factor / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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Homeodomain Proteins
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Nanog Homeobox Protein
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Nanog protein, mouse
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Nr5a2 protein, mouse
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Octamer Transcription Factor-3
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Og2x protein, mouse
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Pou5f1 protein, mouse
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Receptors, Cytoplasmic and Nuclear
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SOXB1 Transcription Factors
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Sox2 protein, mouse
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Sp1 Transcription Factor
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Transcription Factors
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ZFP206 protein, mouse