Insight into immunocytes infiltrations in polymorphous light eruption

Dongyun Lei; Wenjuan Wu; Li Yang; Yan Li; Jiaqi Feng; Lechun Lyu; Li He

doi:10.1016/j.biotechadv.2017.07.006

Insight into immunocytes infiltrations in polymorphous light eruption

Biotechnol Adv. 2017 Nov 1;35(6):751-757. doi: 10.1016/j.biotechadv.2017.07.006. Epub 2017 Jul 17.

Authors

Dongyun Lei¹, Wenjuan Wu¹, Li Yang¹, Yan Li¹, Jiaqi Feng¹, Lechun Lyu², Li He³

Affiliations

¹ Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Institute of Dermatology & Venereology of Yunnan Province, Kunming, Yunnan, China.
² Department of Physiology, School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan, China. Electronic address: lvlechun@kmmu.edu.cn.
³ Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Institute of Dermatology & Venereology of Yunnan Province, Kunming, Yunnan, China. Electronic address: heli2661@163.com.

PMID: 28729211
DOI: 10.1016/j.biotechadv.2017.07.006

Abstract

Polymorphous light eruption (PLE) which is one of the most common photodermatoses has been demonstrated to be immune-mediated disorder. Resistance to UV-induced immunosuppression resulting from differential immune cells infiltration and cytokines secretion has been highlighted in the pathogenesis of PLE. In this study, we reviewed differential patterns of immune cells infiltrations and cytokines secretion that may contribute to PLE occurrence and development.

Keywords: Cytokines; Immune cells; Immunosuppression; Photodermatoses; Polymorphous light eruption.

Publication types

Review

MeSH terms

Cytokines / biosynthesis
Cytokines / genetics*
Dermatitis, Photoallergic / etiology
Dermatitis, Photoallergic / genetics*
Dermatitis, Photoallergic / immunology*
Dermatitis, Photoallergic / physiopathology
Humans
Immune Tolerance / genetics*
Immune Tolerance / radiation effects
Ultraviolet Rays / adverse effects

Substances

Cytokines