Phosphatase activity of soluble epoxide hydrolase

Jan Kramer; Ewgenij Proschak

doi:10.1016/j.prostaglandins.2017.07.002

Phosphatase activity of soluble epoxide hydrolase

Prostaglandins Other Lipid Mediat. 2017 Nov:133:88-92. doi: 10.1016/j.prostaglandins.2017.07.002. Epub 2017 Jul 17.

Authors

Jan Kramer¹, Ewgenij Proschak²

Affiliations

¹ Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60439, Frankfurt am Main, Germany.
² Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60439, Frankfurt am Main, Germany. Electronic address: proschak@pharmchem.uni-frankfurt.de.

PMID: 28729091
DOI: 10.1016/j.prostaglandins.2017.07.002

Abstract

Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that exhibits lipid epoxide hydrolase (sEH-H) and lipid phosphatase activity (sEH-P), with each being located in its own distinct domain. While the epoxide hydrolase activity is well-investigated, the role of the phosphatase domain remains unclear. This article briefly summarizes the evolution, structure and SNPs of the human sEH, with a special focus on the function and postulated role of the N-terminal domain of sEH. Furthermore, the article provides an overview of tools to study sEH-P.

Keywords: Assay systems; Lipid phosphates; Phosphatase; Soluble epoxide hydrolase.

Publication types

Review

MeSH terms

Animals
Epoxide Hydrolases / chemistry*
Epoxide Hydrolases / genetics
Epoxide Hydrolases / metabolism*
Humans
Phosphoric Monoester Hydrolases / metabolism*
Polymorphism, Single Nucleotide
Solubility

Substances

Phosphoric Monoester Hydrolases
Epoxide Hydrolases