Powassan virus (POWV) lineage II is an emerging tickborne flavivirus with an unknown seroprevalence in humans. In a Lyme disease-endemic area, we examined the seroreactivity to POWV in 2 patient cohorts and described the clinical features of the POWV-seroreactive patients. POWV disease might be less neuroinvasive than previously thought.
Keywords: Lyme disease; Powassan virus; United States; deer tick virus; encephalitis viruses; meningitis/encephalitis; serology; tick-borne encephalitis; tickborne; vector-borne infections; viruses; zoonoses.