Data on MyoD reduction by autophagy in C2C12 cells

Yeong-Min Yoo; Yung Chul Park

doi:10.1016/j.dib.2017.06.034

Data on MyoD reduction by autophagy in C2C12 cells

Data Brief. 2017 Jun 24:13:650-654. doi: 10.1016/j.dib.2017.06.034. eCollection 2017 Aug.

Authors

Yeong-Min Yoo^{1

2}, Yung Chul Park^{1

2}

Affiliations

¹ Department of Forest Environment Protection, College of Forest and Environmental Science, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea.
² Institute of Forest Science, College of Forest and Environmental Science, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea.

Abstract

Autophagy is a highly regulated physiologic mechanism in which cells maintain homeostasis by degrading excessive or unnecessary proteins and damaged or aged organelles through the lysosomal machinery (Yorimitsu and Klionsky, 2005) [1]. MyoD is basic helix-loop-helix (bHLH) transcription factors that regulate myoblast proliferation and myogenic differentiation. MyoD is expressed in adult skeletal muscle (Megeney et al., 1996) [2] and adult fibers (Brack et al., 2005) [3]. MyoD is mainly degraded by the ubiquitin-proteasome system (Floyd et al., 2001) [4] and partly by autophagy (Kim et al., 2012) [5]. Data showed that autophagy decreased MyoD protein in C2C12 cells by Western blotting analysis.

Keywords: Autophagy; C2C12 cells; Degradation; MyoD.