Data on Lipocalin 2 and phosphatidylinositol 3-kinase signaling in a methionine- and choline-deficient model of non-alcoholic steatohepatitis

Anastasia Asimakopoulou; Erawan Borkham-Kamphorst; Eddy Van de Leur; Ralf Weiskirchen

doi:10.1016/j.dib.2017.06.048

Data on Lipocalin 2 and phosphatidylinositol 3-kinase signaling in a methionine- and choline-deficient model of non-alcoholic steatohepatitis

Data Brief. 2017 Jul 1:13:644-649. doi: 10.1016/j.dib.2017.06.048. eCollection 2017 Aug.

Authors

Anastasia Asimakopoulou¹, Erawan Borkham-Kamphorst¹, Eddy Van de Leur¹, Ralf Weiskirchen¹

Affiliation

¹ Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.

Abstract

The data presented in this brief report support the research article "Altered mitochondrial and peroxisomal integrity in lipocalin-2-deficient mice with hepatic steatosis" [1, doi: 10.1016/j.bbadis.2017.04.006]. We tested whether the absence of Lipocalin-2 (LCN2) could dysregulate the phosphatidylinositol 3-kinase/protein kinase B (PI3K-PKB) pathway and hepatic homeostasis in Non-Alcoholic-Steatohepatitis (NASH). The article highlights the role of LCN2 in hepatic homeostasis.

Keywords: Fat; Lipocalin 2; MCD; Mitochondria; NASH; Oxidative stress; PIP3.