ILCs and T Cells Competing for Space: More Than a Numbers Game

Christin Friedrich; Georg Gasteiger

doi:10.1016/j.immuni.2017.07.003

ILCs and T Cells Competing for Space: More Than a Numbers Game

Immunity. 2017 Jul 18;47(1):8-10. doi: 10.1016/j.immuni.2017.07.003.

Authors

Christin Friedrich¹, Georg Gasteiger²

Affiliations

¹ Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg Medical Center, 79104 Freiburg, Germany; Institute of Medical Microbiology and Hygiene, University of Mainz Medical Center, 55131 Mainz, Germany.
² Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg Medical Center, 79104 Freiburg, Germany; Institute of Medical Microbiology and Hygiene, University of Mainz Medical Center, 55131 Mainz, Germany; Institute of Systems Immunology, University of Wuerzburg, 97078 Wuerzburg, Germany. Electronic address: georg.gasteiger@uni-wuerzburg.de.

PMID: 28723555
DOI: 10.1016/j.immuni.2017.07.003

Abstract

T cell homeostasis critically depends on interleukin-7 (IL-7). In this issue of Immunity, Martin et al. (2017) provide evidence that IL-7 availability is regulated through a "cytokine sink" involving innate lymphoid cells that compete for and consume IL-7 and thereby restrict T cell homeostasis in lymphoid organs.

Publication types

Comment

MeSH terms

Cytokines
Humans
Immunity, Innate / immunology*
Interleukin-7
Lymphocytes / immunology
T-Lymphocytes*

Substances

Cytokines
Interleukin-7