Co-catalyzed highly selective C(sp3)-H nitration

Yao Zhou; Zhonghe Tang; Qiuling Song

doi:10.1039/c7cc04433j

Co-catalyzed highly selective C(sp³)-H nitration

Chem Commun (Camb). 2017 Aug 8;53(64):8972-8975. doi: 10.1039/c7cc04433j.

Authors

Yao Zhou¹, Zhonghe Tang, Qiuling Song

Affiliation

¹ Institute of Next Generation Matter Transformation, College of Chemical Engineering at Huaqiao University, 668 Jimei Blvd, Xiamen, Fujian 361021, P. R. China. qsong@hqu.edu.cn.

PMID: 28722745
DOI: 10.1039/c7cc04433j

Abstract

A Co-catalyzed highly chemo- and regio-selective nitration of C(sp³)-H was developed. Diverse aliphatic nitro compounds were obtained in good yields, using t-BuONO as a nitrating reagent. Specific nitration of C(sp³)-H instead of C(sp²)-H was achieved via a radical process rather than concerted metalation-deprotonation.